Nips respiratory parameters-Validity of behavioral and physiologic parameters for acute pain assessment of term newborn infants

It has been suggested that leaks from the mask may impair the expiratory trigger cycling mechanism when inspiratory pressure support ventilation PSV is used. The aim of this study was to compare the short-term effect of two different expiratory cycling mechanisms time-cycled vs flow-cycled during noninvasive inspiratory pressure support ventilation NIPSV on patient-ventilator synchronisation in severe hypoxemic respiratory failure. A tight fit of the mask was avoided in order to facilitate air leaks around the mask. The esophageal pressure time product PTPes and tidal swings delta Pes were measured to evaluate the patient's respiratory effort. A subjective "comfort score" and the difference between patient and machine respiratory rate [delta RR p-v ], calculated on esophageal and airway pressure curves, were used as indices of patient-machine interaction.

Nips respiratory parameters

Nips respiratory parameters

Nips respiratory parameters

Nips respiratory parameters

Nips respiratory parameters

Nips respiratory parameters usual regimen is 0. NPPE is a potentially life-threatening complication that develops rapidly after UAO in otherwise healthy Nips respiratory parameters persons who are capable of producing large markedly NIPs. These factors, along with an accurate ventilator weaning protocol system, should allow us to wean patients off the mechanical ventilator in a safe and effective manner. Once the patient has begun to show improvement, dose can be decreased and gradually converted to alternate-day dosing. Eur Respir J. The management of MC should follow a step by step, sequential, and multidisciplinary protocol Swngers fucking pussy 3based on guidelines Nips respiratory parameters the European Federation of Neurological Societies In addition, acute care should be focused on reducing circulating antibody titers with immunologic therapy such as plasmapheresis PEimmunoglobulin IVIgand corticosteroids 2 8 -

Mahogany aircraft models. Electronic supplementary material

Brain and Development. Fact Sheet No. Find articles by Sabeen Mujeeb. Nursing Commons. When comparing the salivary cortisol levels in preterm newborns before and after hydrokinesiotherapy and with term newborns from the mother and Nips respiratory parameters ward, a significant difference was observed between the mean hormone levels. Pulse oximetry is the simplest way to monitor oxygenation and respiratory stability in Porn e-mails infants [ 37 ]. Prevention and management of pain and stress in the neonate. Please review our privacy policy. The pulmonary outcome of a patient with MG or GBS will often depend on the balance between the respiratory muscle strength and the work of breathing. DPNB Nips respiratory parameters often associated with significant complications in case of intravascular injection. When a newborn is exposed to a stressful stimulus, the hypothalamic-pituitary-adrenal axis is activated and releases adrenocorticotropic hormone, which in turn stimulates glucocorticoid secretion by the adrenal gland cortex. Independent sample t-test was used to compare means.

NPPE is a potentially life-threatening complication that develops rapidly after UAO in otherwise healthy young persons who are capable of producing large markedly NIPs.

  • In the neonatal intensive care unit NICU environment, preterm newborns are subject to environmental stress and numerous painful interventions.
  • Temperature ranges do not vary with age.
  • In reality such prediction is impossible, so we are often forced to carefully observe patients in the ICU until they declare themselves.

Published on February 7, Over the past several years, there has been an increased demand for weaning the ventilator patient in a safe and cost-effective environment. Clinical Application Weaning techniques differ considerably from one another. Assuming that all aspects of the above criteria are adequate, negative inspiratory pressure NIP , positive expiratory pressure PEP , and rapid shallow breathing index RSBI should be performed daily.

All aspects of this protocol allow us to perform the first weaning maneuver. The ventilator rate is weaned to a level that allows for acceptable gas exchange at the alveolar level. If the patient shows no signs of respiratory distress and has adequate gas exchange, he or she is weaned to appropriate pressure support settings.

If this maneuver is tolerated, with no existing signs of respiratory distress and an adequate gas exchange, the patient is placed on mist trials, beginning at minute to 1-hour increments.

The end tidal CO2 and saturation, with correlating blood gases, and assessment of respiratory distress and use of accessory muscles should be monitored at all times throughout the weaning process. This model introduces three distinct time points: preweaning, weaning, and weaning outcome.

Decisions made during preweaning involve determining if the patient is ready to begin weaning, selecting an approach to weaning, and deciding on a mode of weaning. During the weaning process, clinicians assess parameters, which include percent of ventilator-free time, percent of minute ventilation requirement supported by mechanical ventilation, myocardial function, oxygenation, nutrition, electrolytes, use of accessory muscles, ventilatory drive, and psychological status.

The National Study Group indicated that it was difficult to find a consistent method of charting progress during the weaning process. The criteria that must be met for complete weaning include: a complete weaning process, where patients spontaneously breathe on their own for hours. It provides a numerical outcome. Hemodynamically stable? Systemically hydrated? Electrolytes within normal limits? Pain controlled? Appropriate level of anxiety and nervousness? Absence of bowel problems diarrhea, constipation, ileus?

Chest x-ray improving or returned to baseline? This is assessed off the ventilator while measuring Absence of adventitious breath sounds? Secretions thin and minimal? Cough and swallow reflexes adequate. Additional for Wean Index 1. With the continual improvement in modes of mechanical ventilation, the process of weaning patients from mechanical ventilation should become less time intensive and decrease the expense of maintaining a mechanically ventilated patient.

These factors, along with an accurate ventilator weaning protocol system, should allow us to wean patients off the mechanical ventilator in a safe and effective manner. Mary P. References 1. Egan DF. Fundamentals of Respiratory Therapy. Knobel A. Weaning from mechanical ventilatory support: refinement of a model.

Am J Crit Care Med. Burns S. Latest Issue Archives. General Assessment ……………. Print This Article. Table 1.

However, Maas et al. Effect of early intervention on premature infants' general movements. The Journal of Pediatrics. Neuroendocrinology Letters. Part I: clinical competencies and neonatal intensive care unit clinical training models.

Nips respiratory parameters

Nips respiratory parameters

Nips respiratory parameters

Nips respiratory parameters. Pediatric Vital Signs Reference Chart

Nursing Commons. Advanced Search. Privacy Copyright. Skip to main content. Author Annette L. Comments Questions or concerns regarding the copyright status of this item may be directed to scholarworks gvsu.

Included in Nursing Commons. During their hospital stay in the NICU, preterm newborns are subject to numerous painful interventions necessary for their survival. Some researchers estimate that a newborn admitted to the NICU is submitted to between 50 and painful bedside procedures daily [ 4 ]. In addition to the painful interventions, preterm infants are exposed to a variety of adverse environmental conditions, including excessive light, loud noises, and frequent handling.

This exposure, when maximized, can cause elevations in circulating cortisol levels, metabolic, behavioral, and physiological changes in the brain microstructure, susceptibility to infection, and delayed neurodevelopment [ 5 — 8 ]. When a newborn is exposed to a stressful stimulus, the hypothalamic-pituitary-adrenal axis is activated and releases adrenocorticotropic hormone, which in turn stimulates glucocorticoid secretion by the adrenal gland cortex.

At high levels, glucocorticoid is considered to be an indicator of physical and psychological stress [ 5 , 6 , 9 — 12 ]. In this context, salivary cortisol measurement is indicated for the neonatal population, as it is a simple, noninvasive, and safe procedure for evaluating the stress threshold of a newborn [ 11 — 14 ].

However, Maas et al. Given the harmful consequences of an unhealthy environment such as the NICU, it is necessary to incorporate daily therapeutic measures, preferably noninvasive procedures, that promote comfort, minimize stress, and provide pain relief.

In recent decades, efforts have been made in multidisciplinary programs regarding the introduction of new concepts related to humanization and care in newborn development [ 17 ].

Paying special attention to pain, stress, and discomfort as well as techniques intended to reduce them can provide a starting point for improved quality of life for preterm newborns hospitalized in neonatal units. Although hydrokinesiotherapy has been used as a therapeutic technique for thousands of years, it is still a therapy that is not well understood nor well accepted in newborn care, and there are few studies on this approach in the literature. Neonatal hydrokinesiotherapy is a therapeutic alternative that allows the newborn to make movements that are facilitated by the aquatic environment, encouraging bone resorption metabolism, pain relief, and relaxation [ 14 , 18 — 23 ].

Although it is considered an appropriate technique because of its many benefits, no studies have evaluated the changes in salivary cortisol measurement caused by neonatal hydrokinesiotherapy. As a method that is simple to execute, nonpharmacological, and of low cost, neonatal hydrokinesiotherapy appears to provide many benefits, including accelerating the growth and development of biological systems in newborns [ 3 , 9 , 18 , 19 , 23 — 25 ].

Given the potential benefits of the technique, the objective of the present study was to investigate the short-term effects of hydrokinesiotherapy on salivary cortisol values in preterm newborns and, secondarily, to evaluate the short-term effects of the technique on the hemodynamics, respiratory parameters, and pain levels of these preterm infants. The study excluded infants with intravascular cannulas intravenous or arterial lines below shoulder level, the presence of umbilical catheterization, the presence of umbilical cord remnants, neurological or heart problems, and the presence of orthopedic or facial malformations that made it impossible to apply the Neonatal Infant Pain Scale NIPS.

Based on the sample size estimate, 15 preterm newborns hospitalized in the NICU who met the inclusion and exclusion criteria were selected on a consecutive basis. For comparison purposes, we evaluated the salivary cortisol values of 15 term newborns, who were healthy and without comorbidities and hospitalized in the infant and mother ward of the same hospital.

After selection, the preterm infants were wrapped in a towel with the body semirelaxed and carefully placed in the liquid environment. To perform the neonatal hydrokinesiotherapy, a plastic bucket near the incubator was used. The protocol lasted 10 minutes as the newborns performed light and slow movements aimed at tactile-kinesthetic stimulation and facilitating the flexed posture of body organization via the effect of the thrusting motion. The hydrokinesiotherapy comprised passive mobilizations of the upper and lower limbs, global stretching, trunk rotation, and tactile, proprioceptive, and vestibular stimulation, finishing with the baby in the fetal position [ 18 ].

At the end of the procedure, the postural organization was maintained, and the infant was wrapped in a towel and placed in an incubator Table 1 and Figure 1. Physiological data were collected 5 minutes before and immediately after the intervention.

Infants undergoing hydrokinesiotherapy. Note the size of the plastic bucket a and the smooth movement of rotation b. The physical therapists responsible for applying the technique Welcy Cassiano de Oliveira Tobinaga and Cirlene de Lima Marinho are both neonatology specialists and undertook an aquatic physical therapy protocol and evaluation scale training over a period of 15 days. To minimize other potential stressors, all samples were obtained between and am because this time is considered to represent the peak cortisol level threshold, as well as being a time when less handling of the newborn, lower activity in the unit, and, consequently, lower noise and light exposure occur [ 11 — 14 ].

Physiological parameters were evaluated before and after neonatal hydrokinesiotherapy to estimate the pain level shown by the newborns included in the study. Respiratory rate, heart rate, peripheral capillary oxygen saturation SpO 2 , and salivary cortisol values were recorded. After this period, the cotton swab was removed from the infant's mouth, and it was returned to the device. A saliva volume of 0.

Pain levels were evaluated using the NIPS. To estimate the sample size, a pilot study in a group of eight preterm newborns was conducted using a protocol identical to that described above. The minimal calculated value for this study consisted of 15 preterm newborns. The Shapiro-Wilk normality test was used to evaluate the data distribution.

Changes in the variables between the two time points before and after hydrokinesiotherapy were evaluated using a paired sample t -test or a Wilcoxon signed-rank test. Cortisol levels were compared using the paired sample t -test or Wilcoxon signed-rank test, depending on whether the groups were independent.

The analyses were performed using the software program Origin Pro 9. Of the 29 participants eligible for evaluation, 15 completed the study Figure 2. The newborns had a mean gestational age of Before neonatal hydrokinesiotherapy, the preterm newborns had a mean salivary cortisol level of 0. After the procedure, the level was reduced to 0. The mean salivary cortisol level of the term newborns was 0.

A comparison of the salivary cortisol levels before and after hydrokinesiotherapy in preterm and term newborns is shown in Figure 3. Regarding hemodynamics and respiratory parameters, the mean heart rate was The mean respiratory rate was The mean axillary temperature was Regarding pain evaluation, the mean NIPS score before the procedure was 0.

After the procedure, the score for all patients was zero. Physiological values measured 5 minutes before and immediately after the intervention. Because of its goal of preventing and treating various clinical conditions, hydrokinesiotherapy is considered a neonatal therapeutic modality and has been shown to be beneficial in clinically stable newborns [ 21 — 23 ].

Several studies have shown that hydrokinesiotherapy helps to reduce pain, stress, irritability, and neuromusculoskeletal changes acquired by newborns during long periods of hospitalization [ 3 , 9 , 18 , 19 , 23 — 25 ]. Another potential application for hydrokinesiotherapy is infants with neonatal abstinence syndrome during the drug withdrawal phase in which sleep disruption and jittery movement are present [ 30 ].

In this study, preterm newborns showed a significant reduction in both heart rate and respiratory rate after neonatal hydrokinesiotherapy. Sweeney [ 23 ] observed decreased heart rates after hydrotherapy, suggesting that this change is associated with the shift to a behavioral state of comfort and relaxation provided by the physical properties of the water.

Harrison et al. Despite the fact that statistically significant reductions in heart and respiratory rates are probably not relevant from a clinical point of view, it is difficult to determine the real impact of these changes on preterm newborns when their physiological and behavioral systems are severely hyperstimulated compared with exposure to intrauterine stimuli [ 35 ].

It is also important to note that although the absolute values were within the limits of normality, the reductions in heart and respiratory rate strongly support the belief that hydrotherapy does not cause stress or pain. In our study, no significant difference was observed in the temperature of the preterm newborns before and after application of the protocol.

Our findings are in line with those of Sweeney [ 23 ], who evaluated the effects of hydrotherapy on term newborns and found that their temperature maintained a pattern within the bounds of normality. If the water temperature is close to that of the neonates, the conduction and convection mechanisms do not have an effect on heat loss.

Pulse oximetry is the simplest way to monitor oxygenation and respiratory stability in preterm infants [ 37 ]. Similar effects were found by Barbosa [ 19 ], who studied preterm newborns that were agitated and crying prior to therapy, with a mean SpO 2 of After the technique, a significant increase was observed in SpO 2 values Interestingly, Harrison et al.

Among the many therapeutic effects of water, improved blood circulation caused by the effect of hydrostatic pressure, which mainly increases blood flow in the alveoli, may at least partly explain the improvement in gas exchange [ 38 ]. In our study, it should be noted that, despite the statistically significant difference between SpO 2 values before and after hydrokinesiotherapy, the clinical relevance is low because the values all fall within the bounds of normality.

However, the respiratory and neurological systems of preterm newborns are exposed to various complications and can never be compared with those of term newborns [ 37 ]. Until the s, it was believed that newborns were unable to feel pain, and many professionals were not concerned about this issue, citing neurological immaturity of the connections responsible for the pain sensation, which possibly increases the pain threshold [ 3 ].

Pain evaluation scales are important tools that can be applied before, during, and after a painful stimulus. NIPS is a newborn pain evaluation scale that is easy to understand and apply clinically which can help newborn healthcare professionals in situations where they wish to evaluate pain or pain relief [ 40 ].

Given that hydrokinesiotherapy is a technique that has rarely been studied in the literature, it would be opportune to evaluate this therapy using NIPS in two respects: from the point of view of hydrokinesiotherapy as both a procedure that can potentially cause pain and, contrariwise, a technique that can relieve pain and stress in the preterm newborn who is subject to constantly repeated or prolonged stimuli within the NICU [ 18 , 19 ].

Despite the fact that the NIPS evaluation of pain perception did not reveal a significant difference, the clinical relevance of our study cannot be disregarded, as a score of zero was observed in all newborns after the intervention, demonstrating an absence of pain and adverse responses to the procedure.

Findings similar to ours were obtained by Barbosa [ 19 ] in a study of 10 preterm newborns where hydrotherapy was performed for 10 minutes in the form of passive mobilization of the upper and lower limbs, global stretching, trunk rotation, and tactile-proprioceptive-vestibular stimulation.

They noted that the NIPS scores remained below three after hydrotherapy mean 0. Interestingly, these authors also observed that NIPS scores increased from 3. Vignochi et al. This shows that positions and techniques that facilitate lower energy consumption, improved sleep quality, and better postural organization promote reductions in the potential harmful effects of hospitalization in the NICU [ 13 ].

The physical properties of water may therefore be used to relieve pain in newborns. It is interesting to note that the circadian cycle of preterm infants is not coordinated with cortisol; this is possibly due to the immaturity of the central nervous system and the afferent and efferent suprachiasmatic nucleus pathways [ 14 ].

However, the circadian cycle is established between 2 and 16 weeks of life, in both premature and term newborns. The circadian cycle of adrenocorticotropic hormone release is related to an increase in its secretion in the morning period, between 5 am and 9 am, and a decrease during the nocturnal period [ 14 ]. As the duration of our protocol including the two data collection periods did not exceed 20 minutes and was always performed between 7 am and 9 am, we believe that the decrease in salivary cortisol after hydrokinesiotherapy could not have been due to the circadian cycle of this hormone.

When comparing the salivary cortisol levels in preterm newborns before and after hydrokinesiotherapy and with term newborns from the mother and infant ward, a significant difference was observed between the mean hormone levels. However, we found that, after hydrokinesiotherapy, the cortisol levels of infants in the NICU were closer to those of the term newborns in the ward.

Interestingly, Cabral et al. The mean cortisol level observed in the control group on the 14th day of life in the infant's home was 1. According to these authors, the findings indicate an adrenal stress response during the first days of hospitalization, which may be related to suppression of the adrenal glands and interference in the stress response caused by the glucocorticoids that are often used during the prenatal period [ 12 ].

Similar to any other study, this work has its limitations. Second, the sample size is relatively small, although this is explained by the fact that only preterm newborns were included. Third, only the short-term effects of neonatal hydrokinesiotherapy were evaluated. Future controlled trials with a larger number of infants that are conducted over a longer period could provide clearer information about the benefits provided by the application of hydrokinesiotherapy in the neonatal environment.

This may affect the incorporation of this technique as routine therapy in the NICU. In conclusion, neonatal hydrotherapy promoted short-term relief from feelings of stress in the present study.

Neonatal hydrokinesiotherapy may be a therapeutic alternative in preterm newborns that is technically easy to administer and of low cost. However, it needs to be studied in randomized, crossover, and blinded trials. The authors declare that there is no conflict of interests regarding the publication of this paper.

National Center for Biotechnology Information , U. Journal List Rehabil Res Pract v. Rehabil Res Pract. Published online Sep 8. Author information Article notes Copyright and License information Disclaimer.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Abstract Background.

Introduction The neonatal intensive care unit NICU in Brazil has experienced major technological breakthroughs in recent years, following the global trend. Methods 2. Intervention After selection, the preterm infants were wrapped in a towel with the body semirelaxed and carefully placed in the liquid environment. Open in a separate window. Figure 1. Table 1 Hydrokinesiotherapy protocol used in this study. Steps Procedures One Fill the bucket with sufficient water to promote immersion up to shoulder level with flotation of the newborn.

Three Remove the newborn from the incubator and transfer them to the bucket in a bent posture organized around the midline, with pulse oximetry monitoring of the upper right limb. Four Ideal: 2 caregivers: one to execute the technique and the other to help with the procedure if necessary.

Six Perform subtle pelvic dissociations with anteroposterior, laterolateral, and superoinferior trunk movements, using the physical properties of the water, such as buoyancy and flotation.

Seven Stimulate active movement of the upper and lower limbs. Eight Facilitate the newborn's trunk rotation, both to the right and to left, using subtle movements with the aid of flotation.

Nine Promote tactile-kinesthetic stimulation using light and slow movements, sliding the newborn in the liquid environment. Ten Repeat the maneuvers described above, and maintain postural organization. Close the protocol after 10 minutes with the newborn in the fetal position. Data Collected To minimize other potential stressors, all samples were obtained between and am because this time is considered to represent the peak cortisol level threshold, as well as being a time when less handling of the newborn, lower activity in the unit, and, consequently, lower noise and light exposure occur [ 11 — 14 ].

Statistical Analysis To estimate the sample size, a pilot study in a group of eight preterm newborns was conducted using a protocol identical to that described above. Figure 2. Figure 3. Table 2 Physiological values measured 5 minutes before and immediately after the intervention.

Understanding negative pressure pulmonary edema

The myasthenic patient in crisis: an update of the management in Neurointensive Care Unit. Myasthenic crisis MC is a complication of MG characterized by worsening muscle weakness, resulting in respiratory failure that requires intubation and mechanical ventilation. It also includes postsurgical patients, in whom exacerbation of muscle weakness from MG causes a delay in extubation. Immunoglobulins, plasma exchange, and steroids are the cornerstones of immunotherapy.

Myasthenic crisis MC is an uncommon life-threatening neurological emergency 1 - 3. It may occur in patients who have previously diagnosed myasthenia gravis MG or may be the onset of the disease, generally during the first year after diagnosis 4 - 6. The hallmark of MC is the bulbar or respiratory failure 1 2 5 7 - The management of these patients is challenging due to the fluctuating nature of the disease 4 5 8 - Prevention and treatment of MC requires admission to intensive care unit ICU — preferably a neuroscience ICU — close observation, and, when necessary, intubation for ventilatory and feeding support 2 8 - In addition, acute care should be focused on reducing circulating antibody titers with immunologic therapy such as plasmapheresis PE , immunoglobulin IVIg , and corticosteroids 2 8 - Despite the growing interest and newer treatment modalities, deficiencies in management still persist.

This paper reviews the available evidence in the detection and treatment of the MC from a multidisciplinary perspective, with the intention to help to correct management. Overall, women are twice as likely as men to be affected 3 The average age of admission with crisis is 59 years By definition, all MG patients with acquired neonatal or autoimmune form showing a respiratory failure due to muscle weakness and requiring ventilatory assistance should be considered in MC 2 4 - 12 Table 1.

Clinical classifications with modifications of the severity of myasthenia gravis. Many drugs exacerbate MG and may determine MC They should be avoided or used with caution. Some examples have been listed in Table 2. It is important to note that telithromycin, a macrolide, is absolutely contraindicated in MG 14 19 - Therefore, initiation of corticosteroids should always occur in a hospital setting, where respiratory function can be monitored 19 Predictors of exacerbation from prednisone include older age, lower score on Myasthenia Severity Scale Table 3 , and bulbar symptoms Live vaccines should be avoided in MG patients receiving immunosuppression 2 7 Contrast agents 20 and electrolyte alterations hypokalemia, hypophosphatemia may exacerbate muscle weakness 2 7.

Thyroid disease, which can coexist with MG, can exacerbate or unmask MG weakness when untreated, while over-replacement with levothyroxine may also cause MC 2 7 If a MG patient requires general anaesthesia, neuromuscular-blocking agents should be used cautiously since they are particularly sensitive to non-depolarizing agents and the response to depolarizing drugs is variable 2 7 The association of MG with thymic pathology is well known.

Table 2. Medication and drugs that may provoke myasthenia crisis. Table 3. Quantitative myasthenia gravis score for disease severity. MG is an autoimmune disorder resulting from antibody-complement-mediated and T-cell-dependent immunologic attack on the postsynaptic membrane of the neuromuscular junction, mainly against acetylcholine receptor AchR 14 27 28 Fig 1.

The antibodies that bind to epitopes of the skeletal muscle end-plate region result in abnormal neuromuscular transmission and clinical weakness 14 27 There are different antibodies directed at the neuromuscular junction and detectable in the plasma Table 4 14 27 AChR antibodies bind to the main immunogenic region of alpha subunit of AChR of postsynaptic membrane resulting in decreased numbers and density of AChR 14 27 Fig 1.

Normal neuromuscular junction and pathophysiology of myasthenia gravis. Acetylcholinesterase scavenges and breaks down unbound ACh. In a separate pathway, neural agrin binds muscle-specific tyrosine kinase MuSK initiating clustering of phosphorylated rapsyn and AChRs, stabilizing the postsynaptic structure opposite the nerve. MuSK initiates clustering of the cytoplasmic protein rapsyn and AChRs and is believed to maintain normal postsynaptic architecture.

In myasthenia gravis caused by antibodies to the AChRs, there is blockade of the binding site for ACh, cross-linking of the AChR with subsequent internalization and reduction in its surface expression, and initiation of complement and cellular inflammatory cascades with damage to the post- and presynaptic structures. The molecular physiology of myasthenia gravis mediated by antibodies to MuSK has not been established.

Table 4. Clinical subtypes and the occurrence of the various muscle autoantibodies in the different subgroups of myasthenia gravis. Patients with MuSK typically are female and have characteristical weakness pattern involving principally bulbar, neck, shoulder, and respiratory muscles 14 27 MuSK is a protein located at the postsynaptic membrane, which is responsible for clustering the AChR at the muscle membrane surface during development, but the function in mature skeletal muscle and its role in pathophysiology of MG is unknown 14 27 Following thymectomy, rise in antistriated muscle antibody titer may be a sign of recurrent tumor Titin is a protein, providing a direct link between mechanical muscle strain and muscle gene activation 14 The RyR is the calcium channel of the sarcoplasmic reticulum involved in excitation-contraction coupling of striated muscle 14 28 - Higher RyR antibody levels are associated with severity 14 28 - Patients with RyR antibodies are characterized by frequent involvement of bulbar, respiratory, and neck muscles 14 28 - Neck weakness at onset is a distinctive feature of patients with RyR antibodies, while respiratory symptoms are found in patients with titin antibodies with and without RyR antibodies 14 28 - Limb involvement with few or no bulbar signs is typical in RyR-antibody-negative MG 28 - Since many thymoma patients have RyR antibodies, neck weakness and nonlimb bulbar distribution of symptoms are initial characteristic features.

Such symptom distribution should raise the suspicion of thymoma 28 - Thymoma and late-onset MG share similar serological profile with high prevalence of titin and RyR antibodies and lower AChR antibody concentrations compared with early-onset MG 29 Finally, there is a remaining group of patients who do not have either AChR or MuSK antibodies and they actually are considered seronegative 14 Clinically they are similar to patients with AChR antibodies.

During MC, the respiratory failure can be hypoxemic, hypercapnic, or both and result from poor airway protection, inadequate secretions clearance, and hypoventilation.

Bulbar oropharyngeal muscle dysfunction may be the predominant feature in some patients The dysfunction of bulbar muscles alters cough, swallowing reflexes, as well as sigh mechanisms 2 5 7 9 - 11 31 Signs of bulbar weakness include dysphagia, nasal regurgitation, nasal and staccato speech, jaw and tongue weakness, and bifacial paresis It is difficult to handle secretions that accumulate in the oropharynx. Upper airway patent is lost 2 5 7 9 - 11 31 These alterations increase the likelihood of microaspiration, atelectasis, upper airway resistance, dead space, and work of breathing 2 5 7 9 - 11 31 Muscle weakness in AchR-MG tends to initially affect intercostals and accessory muscles and then the diaphragm 7.

The recruitment of accessory muscles indicates significant inspiratory weakness Weak cough or difficulty in counting notes weakness of expiratory muscles Anxiety, accompanied by tachycardia and tachypnea, may be the first sign of air hunger Respiratory muscles are unable to maintain adequate tidal volume. Fig 2. Pathophysiology of myasthenic crisis. The signs of MC should be sought in all patients with MG, even when they do not complain weakness because central ventilatory drive usually remains intact during crisis; so, even when minute ventilation response to CO 2 is poor, the generalized weakness can mask the usual signs of respiratory distress.

Respiratory muscles may suddenly fatigue, producing precipitous respiratory collapse In addition, some patients may present with respiratory insufficiency out of proportion to limb or bulbar weakness 2 5 7 9 - 11 31 - In rare cases of MC, ventilatory failure is the only clinically overt manifestation 34 MC is an acute respiratory failure due to worsening MG, characterized by forced vital capacity FVC below 1 L, negative inspiratory force NIF of 20 cm H 2 O or less, and the need for ventilatory support 2 5 7 9 - 11 31 - Arterial blood gas analysis commonly shows hypercarbia before hypoxia.

There should be a low threshold for endotracheal intubation due to rapid deterioration of bulbar and respiratory muscles. For these reasons, a strict monitoring of respiratory status with regular bedside pulmonary function testing is appropriate 2 5 7 9 - 11 31 - The presence or worsening of clinical features, such as progressive muscle weakness arms, limbs , palpebral ptosis, bulbar muscle envolvement, and disphagia together with the presence of respiratory distress dyspnea, shortness of breath, tachypnea, use of accessory muscles may help to identify patients at risk for MC 2 5 7 9 - 11 31 - If MC is the first presentation of the disease, the specific clinical features of the myasthenic state cannot be evident.

These patients quite suddenly show a severe respiratory distress, facial weakness, airway collapse, and muscle failure. Initially, oxygenation is preserved A suspected clinical diagnosis should be confirmed using electrophysiological, pharmacological, and laboratory testing 2 7 14 17 36 , usually not available on an emergent basis RNS depletes Ach stores at neuromuscular junction, reducing the safety factor and the probability of successful neuromuscular transmission CMAP becomes reduced in amplitude and area 14 17 In patients with respiratory involvement, phrenic and long thoracic nerves should also be tested The Tensilon edrophonium test is useful in diagnosing MG and in distinguishing MC from cholinergic crisis 2 7 14 Edrophonium temporarily improves the safety factor of neuromuscular transmission and may elicit improved muscle strength 2 7 14 Once airway and ventilation are secured, give an initial dose of 1—2 mg and watch for 1 minute, then give 3 mg, and another 3 mg if neccesary 14 Typical side effects of sweating, tearing, fasciculations, and abdominal cramping may indicate peak edrophonium effect.

Observe for possible serious adverse effects such as hypotension or arrhythmias and have always atropine available as antidote 14 If muscle strength improves within 1 minute of any dose increment, test is positive and no further edrophonium needs to be administered 14 Patients with a cholinergic crisis may respond to edrophonium challenge by increasing salivation and bronchopulmonary secretions, diaphoresis, and gastric motility 2 5 7 14 These changes should be managed expectantly, as the half-life of edrophonium is short 10 min.

In addition, worsening of bulbar and respiratory symptoms in MuSK-MG after anticholinesterase administration is known and could confound the clinical diagnosis If the patient requires ventilatory support there is no need to distinguish the two crisis entities False-positives have been also reported in lower motor neuron diseases and brainstem tumors

Nips respiratory parameters